Humalog vs. Novolog.
It wasn't until recently that I started thinking about building up a tolerance to insulin. Do you build up a chemical familiarity, a resistance of sorts, to a drug after taking it for ... oh, say a few decades? Do PWD eventually become the Dread Pirate Roberts, building up a tolerance to iocane powder?
"I realize this is probably ridiculous, and I'm sure there aren't any studies on this," I said to my doctor the other week. "But it has prompted me to want to try a different kind of fast acting insulin, to see if I have better results. Is that something I'm able to do, to have a script written for a one-off in order to assess how the insulin might work for me?"
"We can do that."
And I left the appointment, expecting my pharmacy to auto-dial me when my order was complete.
Instead, a three-month supply of Novolog ended up on my doorstep, having been accidentally shuttled through my mail order pharmacy and eating up my insurance order that was intended for my normal course of Humalog. Which is why I'm experimenting with Novolog for the next few months, as a result of a shipping error.
I've been taking Humalog for over ten years, after switching from Regular insulin before starting on my insulin pump, so I feel like I'm familiar with how Humalog acts in my pump and on my blood sugars. Switching to a different, but similar, rapid-acting analog should hopefully be a seamless transition. Last night was my first pump-load of Novolog, despite the last unopened bottle of Humalog in my stash. (I didn't want to use up the Humalog entirely, then switch to Novolog, because if I absolutely hated the new insulin, I'd be stuck with it.)
So far, last night was entirely uneventful, and the biggest change I've noticed (in less than 24 hours of use) is that the bottle of Novolog plays host to way more bubbles, which I hope doesn't translate to a bubblier reservoir. I'll have a better sense of how this insulin plays once I dial in a few meal boluses and then watch the Dexcom graph play out.
Has anyone switched from Humalog to Novolog? Or Novolog to Humalog? The responses to this question, when I posted it on Facebook, varied quite a bit. Did you notice any changes? Does it all come out in the wash? (And if that's the case, why were you washing it?) Or is it like the Pepsi Challenge, where some people just can't tell the difference and others are left with a bad taste in their mouths?